Anti-DDB2 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-DDB2 Polyclonal Antibody

品牌:solarbio | 货号:K006726P

英文名称 Anti-DDB2 Polyclonal Antibody
宿主 Rabbit
别名 XPE;DDBB;UV-DDB2
应用 IHC
稀释比例 IHC 1:30-150.
交叉反应 Human Mouse
蛋白分子量 48kDa
Gene ID 1643
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human DDB2
性状 液体
Public Immunogen Range Recombinant protein of human DDB2
Subcellular Locations Nucleus
Swiss Prot Q92466
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.