Anti-IL21R Polyclonal Antibody
品牌:solarbio | 货号:K006658P
英文名称 |
Anti-IL21R Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
NILR;CD360 |
应用 |
IHC |
稀释比例 |
IHC 1:25-100. |
交叉反应 |
Human |
蛋白分子量 |
59kDa |
Gene ID |
50615 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human IL21R |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human IL21R |
Subcellular Locations |
Cytoplasm |
Swiss Prot |
Q9HBE5 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. |