Anti-PSEN2 Polyclonal Antibody
品牌：solarbio | 货号：K005411P
| 英文名称 | Anti-PSEN2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AD3L;AD4;CMD1V;PS2;STM2 |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 50kDa |
| Gene ID | 5664 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human PSEN2 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human PSEN2 |
| Subcellular Locations | Endoplasmic reticulum membrane Golgi apparatus membrane Multi-pass membrane protein |
| Swiss Prot | P49810 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Alzheimer’s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. |