Anti-ABCC2 Polyclonal Antibody
品牌：solarbio | 货号：K005813P
| 英文名称 | Anti-ABCC2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ABC30;CMOAT;DJS;MRP2;cMRP |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human |
| 蛋白分子量 | 174kDa |
| Gene ID | 1244 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ABCC2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ABCC2 |
| Subcellular Locations | Apical cell membrane Multi-pass membrane protein |
| Swiss Prot | Q92887 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. |