Anti-CD5 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-CD5 Polyclonal Antibody

品牌:solarbio | 货号:K007995P

英文名称 Anti-CD5 Polyclonal Antibody
宿主 Rabbit
别名 T1;LEU1
应用 IHC
稀释比例 IHC 1:30-150.
交叉反应 Human Mouse Rat
蛋白分子量 55kDa
Gene ID 921
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human CD5
性状 液体
Public Immunogen Range A synthetic peptide of human CD5
Subcellular Locations Membrane
Swiss Prot P06127
克隆类型 Polyclonal Antibody
背景资料 CD5 (also designated Lyt-1) has been identified as a transmembrane glycoprotein that is expressed on 70% of normal peripheral blood lymphocytes and on virtually all T lymphocytes in thymus and peripheral blood. Activation of T cells through the T cell receptor (TCR) results in tyrosine phosphorylation of CD5, and the absence of CD5 renders T cells hyper-responsive to TCR-mediated activation. CD5 associates with the TCR/ CD3-ζ chain and with the Src family kinase Lck p56.?In vitro?studies have shown a 10- to 15-fold increase in the kinase activity of Lck bound to CD5. The B cell antigen, CD72, serves as a receptor for CD5. The consequence of CD5 binding to its cognate receptor is still in question and likely plays a role in thymic selection. May act as a receptor in regulating T-cell proliferation.