Anti-CD5 Polyclonal Antibody
品牌：solarbio | 货号：K007995P
| 英文名称 | Anti-CD5 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | T1;LEU1 |
| 应用 | IHC |
| 稀释比例 | IHC 1:30-150. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 55kDa |
| Gene ID | 921 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human CD5 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human CD5 |
| Subcellular Locations | Membrane |
| Swiss Prot | P06127 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | CD5 (also designated Lyt-1) has been identified as a transmembrane glycoprotein that is expressed on 70% of normal peripheral blood lymphocytes and on virtually all T lymphocytes in thymus and peripheral blood. Activation of T cells through the T cell receptor (TCR) results in tyrosine phosphorylation of CD5, and the absence of CD5 renders T cells hyper-responsive to TCR-mediated activation. CD5 associates with the TCR/ CD3-ζ chain and with the Src family kinase Lck p56.?In vitro?studies have shown a 10- to 15-fold increase in the kinase activity of Lck bound to CD5. The B cell antigen, CD72, serves as a receptor for CD5. The consequence of CD5 binding to its cognate receptor is still in question and likely plays a role in thymic selection. May act as a receptor in regulating T-cell proliferation. |