Anti-ARHGEF3 Polyclonal Antibody
品牌：solarbio | 货号：K008323P
| 英文名称 | Anti-ARHGEF3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | GEF3;STA3;XPLN |
| 应用 | IHC |
| 稀释比例 | IHC 1:25-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 60/64/37kDa |
| Gene ID | 50650 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ARHGEF3 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ARHGEF3 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q9NR81 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |