Anti-SELPLG Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-SELPLG Polyclonal Antibody

品牌:solarbio | 货号:K008226P

英文名称 Anti-SELPLG Polyclonal Antibody
宿主 Rabbit
别名 CLA;CD162;PSGL1;PSGL-1
应用 IHC
稀释比例 IHC 1:50-200.
交叉反应 Human
蛋白分子量 43/45kDa
Gene ID 6404
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human SELPLG
性状 液体
Public Immunogen Range Recombinant protein of human SELPLG
Subcellular Locations Cytoplasm
Swiss Prot Q14242
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.