Anti-SELPLG Polyclonal Antibody
品牌:solarbio | 货号:K008226P
英文名称 |
Anti-SELPLG Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
CLA;CD162;PSGL1;PSGL-1 |
应用 |
IHC |
稀释比例 |
IHC 1:50-200. |
交叉反应 |
Human |
蛋白分子量 |
43/45kDa |
Gene ID |
6404 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human SELPLG |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human SELPLG |
Subcellular Locations |
Cytoplasm |
Swiss Prot |
Q14242 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants. |