Anti-GRPR Polyclonal Antibody
品牌：solarbio | 货号：K007491P
| 英文名称 | Anti-GRPR Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | BB2 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 43kDa |
| Gene ID | 2925 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human GRPR |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human GRPR |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P30550 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. |