Anti-CSF1R Polyclonal Antibody
品牌:solarbio | 货号:K003558P
英文名称 |
Anti-CSF1R Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
C-FMS;CD115;CSF-1R;CSFR;FIM2;FMS;HDLS;M-CSF-R |
应用 |
WB |
稀释比例 |
WB 1:500-2000. |
交叉反应 |
Human Mouse |
蛋白分子量 |
108kDa |
Gene ID |
1436 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human CSF1R |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human CSF1R |
Subcellular Locations |
Cell membrane Single-pass type I membrane protein |
Swiss Prot |
P07333 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. |