Anti-Bcl-xL Polyclonal Antibody
品牌：solarbio | 货号：K106432P
| 英文名称 | Anti-Bcl-xL Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | Bcl-2-like protein 1;BCL2L1;BCL2L;BCLX;Bcl2-L-1 |
| 应用 | WB |
| 稀释比例 | WB 1:3000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 22kDa |
| Gene ID | 598 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human Bcl-xL |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human Bcl-xL |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q07817 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release |