Anti-VRK1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-VRK1 Polyclonal Antibody

品牌:solarbio | 货号:K007262P

英文名称 Anti-VRK1 Polyclonal Antibody
宿主 Rabbit
别名 PCH1;PCH1A
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:25-100.
交叉反应 Human Mouse
蛋白分子量 45kDa
Gene ID 7443
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human VRK1
性状 液体
Public Immunogen Range Recombinant protein of human VRK1
Subcellular Locations Cytoplasm Nucleus
Swiss Prot Q99986
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.?