Anti-FGD4 Polyclonal Antibody
品牌：solarbio | 货号：K005934P
| 英文名称 | Anti-FGD4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CMT4H;FRABP;ZFYVE6 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 87kDa |
| Gene ID | 121512 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human FGD4 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human FGD4 |
| Subcellular Locations | Cell projection Cytoplasm cytoskeleton filopodium |
| Swiss Prot | Q96M96 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |