Anti-MYLK Polyclonal Antibody
品牌：solarbio | 货号：K005630P
| 英文名称 | Anti-MYLK Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AAT7;KRP;MLCK;MLCK1;MLCK108;MLCK210;MSTP083;MYLK1;smMLCK |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 211kDa |
| Gene ID | 4638 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human MYLK |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human MYLK |
| Subcellular Locations | Cell projection Cleavage furrow Cytoplasm cytoskeleton lamellipodium |
| Swiss Prot | Q15746 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3′ region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. |