Anti-PCSK9 Polyclonal Antibody
品牌：solarbio | 货号：K005510P
| 英文名称 | Anti-PCSK9 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | FH3;HCHOLA3;LDLCQ1;NARC-1;NARC1;PC9 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 74kDa |
| Gene ID | 255738 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human PCSK9 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human PCSK9 |
| Subcellular Locations | Cell surface Cytoplasm Endoplasmic reticulum Endosome Golgi apparatus Lysosome Secreted |
| Swiss Prot | Q8NBP7 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. |