Anti-GLUD1 Polyclonal Antibody
品牌：solarbio | 货号：K005354P
| 英文名称 | Anti-GLUD1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | GDH;GDH1;GLUD |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:100-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 61kDa |
| Gene ID | 2746 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human GLUD1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human GLUD1 |
| Subcellular Locations | Mitochondrion matrix |
| Swiss Prot | P00367 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. |