Anti-GLUD1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-GLUD1 Polyclonal Antibody

品牌:solarbio | 货号:K005354P

英文名称 Anti-GLUD1 Polyclonal Antibody
宿主 Rabbit
别名 GDH;GDH1;GLUD
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:100-200.
交叉反应 Human Mouse Rat
蛋白分子量 61kDa
Gene ID 2746
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human GLUD1
性状 液体
Public Immunogen Range Recombinant protein of human GLUD1
Subcellular Locations Mitochondrion matrix
Swiss Prot P00367
克隆类型 Polyclonal Antibody
背景资料 This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.