Anti-AIFM1 Polyclonal Antibody
品牌：solarbio | 货号：K003425P
| 英文名称 | Anti-AIFM1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AIF;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD;PDCD8 |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 67kDa |
| Gene ID | 9131 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human AIFM1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human AIFM1 |
| Subcellular Locations | Cytoplasm Mitochondrion inner membrane Mitochondrion intermembrane space Nucleus perinuclear region |
| Swiss Prot | O95831 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. |