Anti-CRYAA Polyclonal Antibody
品牌：solarbio | 货号：K004164P
| 英文名称 | Anti-CRYAA Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CRYA1;CTRCT9;HSPB4 |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-100. |
| 交叉反应 | Human Mouse Rat Zebrafish |
| 蛋白分子量 | 20kDa |
| Gene ID | 1409 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CRYAA |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CRYAA |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P02489 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). |