Anti-STAT3 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-STAT3 Polyclonal Antibody

品牌:solarbio | 货号:K004046P

英文名称 Anti-STAT3 Polyclonal Antibody
宿主 Rabbit
别名 ADMIO;ADMIO1;APRF;HIES
应用 IHC
稀释比例 IHC 1:50-100.
交叉反应 Human Mouse Rat
蛋白分子量 88kDa
Gene ID 6774
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human STAT3
性状 液体
Public Immunogen Range Recombinant protein of human STAT3
Subcellular Locations Cytoplasm Nucleus
Swiss Prot P40763
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.