Anti-LIMK2 Polyclonal Antibody
品牌：solarbio | 货号：K003977P
| 英文名称 | Anti-LIMK2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | LIMK2 |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 72kDa |
| Gene ID | 3985 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human LIMK2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human LIMK2 |
| Subcellular Locations | Cytoplasm Nucleus Nucleus |
| Swiss Prot | P53671 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. |