Anti-SRGAP1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-SRGAP1 Polyclonal Antibody

品牌:solarbio | 货号:K007855P

英文名称 Anti-SRGAP1 Polyclonal Antibody
宿主 Rabbit
别名 ARHGAP13
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:25-100.
交叉反应 Human Mouse
蛋白分子量 124kDa
Gene ID 57522
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human SRGAP1
性状 液体
Public Immunogen Range A synthetic peptide of human SRGAP1
Subcellular Locations Cytoplasm Nucleus
Swiss Prot Q7Z6B7
克隆类型 Polyclonal Antibody
背景资料 SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 ultimately leads to a decrease in actin polymerization.