Anti-SRGAP1 Polyclonal Antibody
品牌:solarbio | 货号:K007855P
英文名称 |
Anti-SRGAP1 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
ARHGAP13 |
应用 |
WB IHC |
稀释比例 |
WB 1:500-2000. IHC 1:25-100. |
交叉反应 |
Human Mouse |
蛋白分子量 |
124kDa |
Gene ID |
57522 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human SRGAP1 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human SRGAP1 |
Subcellular Locations |
Cytoplasm Nucleus |
Swiss Prot |
Q7Z6B7 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 ultimately leads to a decrease in actin polymerization. |