Anti-CDX4 Polyclonal Antibody
品牌：solarbio | 货号：K007974P
| 英文名称 | Anti-CDX4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | Homeobox protein CDX-4;Caudal-type homeobox protein 4 |
| 应用 | WB |
| 稀释比例 | WB 1:200-1000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 30kDa |
| Gene ID | 1046 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human CDX4 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human CDX4 |
| Swiss Prot | O14627 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Cdx1, Cdx2 and Cdx4 are members of the caudal-type homeobox family of genes, which are homologs of the Drosophila caudal gene required for anterior-posterior regional identity. The proteins encoded by these genes are transcription factors which play an important role in development by regulating the expression of Hox genes. Hox genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. Cdx4 is a major positive regulator of the expression of all Hox family members. Due to its critical role as a regulator, Cdx4 is a direct target of the canonical Wnt pathway. The loss of Cdx4 can result in the development of an expanded hindbrain, while the overexpression of Cdx4 may cause the hindbrain to lose its distinct segmental features and resemble the spinal cord. |