Anti-MXI1 Polyclonal Antibody
品牌:solarbio | 货号:K004692P
英文名称 |
Anti-MXI1 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
MAD2;MXD2;MXI;bHLHc11 |
应用 |
WB IF |
稀释比例 |
WB 1:500-2000. IF 1:50-100. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
26kDa |
Gene ID |
4601 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human MXI1 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human MXI1 |
Subcellular Locations |
Nucleus |
Swiss Prot |
P50539 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. |