Anti-MXI1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-MXI1 Polyclonal Antibody

品牌:solarbio | 货号:K004692P

英文名称 Anti-MXI1 Polyclonal Antibody
宿主 Rabbit
别名 MAD2;MXD2;MXI;bHLHc11
应用 WB IF
稀释比例 WB 1:500-2000. IF 1:50-100.
交叉反应 Human Mouse Rat
蛋白分子量 26kDa
Gene ID 4601
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human MXI1
性状 液体
Public Immunogen Range Recombinant protein of human MXI1
Subcellular Locations Nucleus
Swiss Prot P50539
克隆类型 Polyclonal Antibody
背景资料 Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.