Anti-CSTB Polyclonal Antibody
品牌：solarbio | 货号：K003707P
| 英文名称 | Anti-CSTB Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CPI-B;CST6;EPM1;EPM1A;PME;STFB;ULD |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 11kDa |
| Gene ID | 1476 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CSTB |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CSTB |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P04080 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. |