Anti-ATF1 Polyclonal Antibody
品牌:solarbio | 货号:K004213P
英文名称 |
Anti-ATF1 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
EWS-ATF1;FUS/ATF-1;TREB36 |
应用 |
WB |
稀释比例 |
WB 1:500-2000. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
29kDa |
Gene ID |
466 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human ATF1 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human ATF1 |
Subcellular Locations |
Nucleus |
Swiss Prot |
P18846 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. |