Anti-ATF1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-ATF1 Polyclonal Antibody

品牌:solarbio | 货号:K004213P

英文名称 Anti-ATF1 Polyclonal Antibody
宿主 Rabbit
别名 EWS-ATF1;FUS/ATF-1;TREB36
应用 WB
稀释比例 WB 1:500-2000.
交叉反应 Human Mouse Rat
蛋白分子量 29kDa
Gene ID 466
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human ATF1
性状 液体
Public Immunogen Range Recombinant protein of human ATF1
Subcellular Locations Nucleus
Swiss Prot P18846
克隆类型 Polyclonal Antibody
背景资料 This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.