Anti-HDAC5 Polyclonal Antibody
品牌:solarbio | 货号:K005072P
英文名称 |
Anti-HDAC5 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
HD5;NY-CO-9 |
应用 |
WB IF |
稀释比例 |
WB 1:500-2000. IF 1:20-50. |
交叉反应 |
Human |
蛋白分子量 |
122kDa |
Gene ID |
10014 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human HDAC5 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human HDAC5 |
Subcellular Locations |
Cytoplasm Nucleus |
Swiss Prot |
Q9UQL6 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. |