Anti-POMC Polyclonal Antibody
品牌：solarbio | 货号：K007425P
| 英文名称 | Anti-POMC Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | LPH;MSH;NPP;POC;ACTH;CLIP;OBAIRH |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:25-50. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 29kDa |
| Gene ID | 5443 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human POMC |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human POMC |
| Subcellular Locations | Secreted |
| Swiss Prot | P01189 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. |