Anti-ERBB4 Polyclonal Antibody
品牌：solarbio | 货号：K004339P
| 英文名称 | Anti-ERBB4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ALS19;HER4;p180erbB4 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-1000. IHC 1:50-100. |
| 交叉反应 | Mouse Rat |
| 蛋白分子量 | 147kDa |
| Gene ID | 2066 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ERBB4 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ERBB4 |
| Subcellular Locations | Cell membrane Mitochondrion Nucleus Single-pass type I membrane protein |
| Swiss Prot | Q15303 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |