Anti-DDB1 Polyclonal Antibody
品牌：solarbio | 货号：K003523P
| 英文名称 | Anti-DDB1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | DDBA;UV-DDB1;XAP1;XPCE;XPE;XPE-BF |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-1000. IHC 1:50-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 127kDa |
| Gene ID | 1642 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human DDB1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human DDB1 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q16531 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) – an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. |