Anti-RAD50 Polyclonal Antibody
品牌:solarbio | 货号:K003583P
英文名称 |
Anti-RAD50 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
NBSLD;RAD502;hRad50 |
应用 |
WB IP |
稀释比例 |
WB 1:500-2000. IP 1:20-50. |
交叉反应 |
Human MouseRat |
蛋白分子量 |
154kDa |
Gene ID |
10111 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human RAD50 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human RAD50 |
Subcellular Locations |
Chromosome Nucleus telomere |
Swiss Prot |
Q92878 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder. |