Anti-USP8 Polyclonal Antibody
品牌：solarbio | 货号：K106918P
| 英文名称 | Anti-USP8 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | KIAA0055;UBPY;hUBPy;Ubiquitin thioesterase 8 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:5000-8000. IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 128/115kDa |
| Gene ID | 9101 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human USP8 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human USP8 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P40818 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both ‘Lys-48’ an ‘Lys-63’-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. |