Anti-ATF6 Polyclonal Antibody
品牌：solarbio | 货号：K106483P
| 英文名称 | Anti-ATF6 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ACHM7;ATF6A;ATF6-alpha;ESTM49;FLJ21663 |
| 应用 | WB |
| 稀释比例 | WB 1:3000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 115kDa |
| Gene ID | 22926 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human ATF6 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human ATF6 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P18850 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. |