Anti-BCL2A1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-BCL2A1 Polyclonal Antibody

品牌:solarbio | 货号:K008089P

英文名称 Anti-BCL2A1 Polyclonal Antibody
宿主 Rabbit
别名 GRS;BFL1;ACC-1;ACC-2;HBPA1;BCL2L5
应用 WB IHC
稀释比例 WB 1:200-1000. IHC 1:25-100.
交叉反应 Human Mouse
蛋白分子量 20kDa
Gene ID 597
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human BCL2A1
性状 液体
Public Immunogen Range Recombinant protein of human BCL2A1
Subcellular Locations Cytoplasm
Swiss Prot Q16548
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.