Anti-BCL2A1 Polyclonal Antibody
品牌：solarbio | 货号：K008089P
| 英文名称 | Anti-BCL2A1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | GRS;BFL1;ACC-1;ACC-2;HBPA1;BCL2L5 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:25-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 20kDa |
| Gene ID | 597 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human BCL2A1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human BCL2A1 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q16548 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |