Anti-BCL2A1 Polyclonal Antibody
品牌:solarbio | 货号:K008089P
英文名称 |
Anti-BCL2A1 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
GRS;BFL1;ACC-1;ACC-2;HBPA1;BCL2L5 |
应用 |
WB IHC |
稀释比例 |
WB 1:200-1000. IHC 1:25-100. |
交叉反应 |
Human Mouse |
蛋白分子量 |
20kDa |
Gene ID |
597 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human BCL2A1 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human BCL2A1 |
Subcellular Locations |
Cytoplasm |
Swiss Prot |
Q16548 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |