Anti-GCH1 Polyclonal Antibody
品牌：solarbio | 货号：K007506P
| 英文名称 | Anti-GCH1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | GCH;DYT5;DYT14;DYT5a;GTPCH1;HPABH4B;GTP-CH-1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:5-20. |
| 交叉反应 | Human |
| 蛋白分子量 | 28kDa |
| Gene ID | 2643 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human GCH1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human GCH1 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P30793 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. |