Anti-GCH1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-GCH1 Polyclonal Antibody

品牌:solarbio | 货号:K007506P

英文名称 Anti-GCH1 Polyclonal Antibody
宿主 Rabbit
别名 GCH;DYT5;DYT14;DYT5a;GTPCH1;HPABH4B;GTP-CH-1
应用 WB IHC
稀释比例 WB 1:200-1000. IHC 1:5-20.
交叉反应 Human
蛋白分子量 28kDa
Gene ID 2643
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human GCH1
性状 液体
Public Immunogen Range A synthetic peptide of human GCH1
Subcellular Locations Cytoplasm
Swiss Prot P30793
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.