Anti-GCH1 Polyclonal Antibody
品牌:solarbio | 货号:K007506P
英文名称 |
Anti-GCH1 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
GCH;DYT5;DYT14;DYT5a;GTPCH1;HPABH4B;GTP-CH-1 |
应用 |
WB IHC |
稀释比例 |
WB 1:200-1000. IHC 1:5-20. |
交叉反应 |
Human |
蛋白分子量 |
28kDa |
Gene ID |
2643 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human GCH1 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human GCH1 |
Subcellular Locations |
Cytoplasm |
Swiss Prot |
P30793 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. |