Anti-ALKBH8 Polyclonal Antibody
品牌：solarbio | 货号：K007253P
| 英文名称 | Anti-ALKBH8 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ABH8;TRM9;TRMT9 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:25-100. |
| 交叉反应 | Human |
| 蛋白分子量 | 75kDa |
| Gene ID | 91801 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Full length fusion protein |
| 性状 | 液体 |
| Public Immunogen Range | Full length fusion protein |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q96BT7 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | ALKBH8 (alkylated DNA repair protein AlkB homolog 8) is a 664 amino acid protein that is encoded by a gene located on chromosome 11. ALKBH8 contains one RRM (RNA recognition motif) domain and belongs to the AlkB family of proteins. ALKBH8 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. Three isoforms exist for ALKBH8 due alternative splicing of the gene. |