Anti-HIF1AN Polyclonal Antibody
品牌:solarbio | 货号:K007237P
英文名称 |
Anti-HIF1AN Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
FIH1 |
应用 |
WB IHC |
稀释比例 |
WB 1:200-1000. IHC 1:25-100. |
交叉反应 |
Human Mouse |
蛋白分子量 |
40kDa |
Gene ID |
55662 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Full length fusion protein |
性状 |
液体 |
Public Immunogen Range |
Full length fusion protein |
Subcellular Locations |
Nucleus Cytoplasm |
Swiss Prot |
Q9NWT6 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Hydroxylates HIF-1 alpha at ‘Asp-803’ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. |