Anti-HIF1AN Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-HIF1AN Polyclonal Antibody

品牌:solarbio | 货号:K007237P

英文名称 Anti-HIF1AN Polyclonal Antibody
宿主 Rabbit
别名 FIH1
应用 WB IHC
稀释比例 WB 1:200-1000. IHC 1:25-100.
交叉反应 Human Mouse
蛋白分子量 40kDa
Gene ID 55662
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Full length fusion protein
性状 液体
Public Immunogen Range Full length fusion protein
Subcellular Locations Nucleus Cytoplasm
Swiss Prot Q9NWT6
克隆类型 Polyclonal Antibody
背景资料 Hydroxylates HIF-1 alpha at ‘Asp-803’ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively.