Anti-SMC1A Polyclonal Antibody
品牌：solarbio | 货号：K007184P
| 英文名称 | Anti-SMC1A Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | SMC1;SMCB;CDLS2;SB1.8;SMC1L1;DXS423E;SMC1alpha |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:25-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 143kDa |
| Gene ID | 8243 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human SMC1A |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human SMC1A |
| Subcellular Locations | Nucleus |
| Swiss Prot | Q14683 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. |