Anti-NR0B2 Polyclonal Antibody
品牌：solarbio | 货号：K006829P
| 英文名称 | Anti-NR0B2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | SHP;SHP1 |
| 应用 | IHC |
| 稀释比例 | IHC 1:30-150. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 28kDa |
| Gene ID | 8431 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human NR0B2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human NR0B2 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q15466 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.? |