Anti-ABL1 Polyclonal Antibody
品牌:solarbio | 货号:K006660P
英文名称 |
Anti-ABL1 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
ABL;JTK7;p150;c-ABL;v-abl;c-ABL1;bcr/abl |
应用 |
IHC |
稀释比例 |
IHC 1:50-200. |
交叉反应 |
Human Mouse |
蛋白分子量 |
123kDa |
Gene ID |
25 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human ABL1 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human ABL1 |
Subcellular Locations |
Cytoplasm |
Swiss Prot |
P00519 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.? |