Anti-Phospho-MDM2-S166 Polyclonal Antibody
品牌:solarbio | 货号:K006196P
英文名称 |
Anti-Phospho-MDM2-S166 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
ACTFS;HDMX;hdm2 |
应用 |
WB IF |
稀释比例 |
WB 1:500-1000. IF 1:50-100. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
55kDa |
Gene ID |
4193 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A phospho specific peptide corresponding to residues surrounding S166 of human MDM2 |
性状 |
液体 |
Public Immunogen Range |
A phospho specific peptide corresponding to residues surrounding S166 of human MDM2 |
Subcellular Locations |
Cytoplasm Nucleus nucleolus nucleoplasm |
Swiss Prot |
Q00987 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. |