Anti-PTTG1 Polyclonal Antibody
品牌：solarbio | 货号：K005746P
| 英文名称 | Anti-PTTG1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | EAP1;HPTTG;PTTG;TUTR1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:100-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 22kDa |
| Gene ID | 9232 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PTTG1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PTTG1 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | O95997 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. |