Anti-HLA-DRB1 Polyclonal Antibody
品牌：solarbio | 货号：K005389P
| 英文名称 | Anti-HLA-DRB1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | DRB1;HLA-DR1B;HLA-DRB;SS1 |
| 应用 | WB IF |
| 稀释比例 | WB 1:500-2000. IF 1:50-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 30kDa |
| Gene ID | 3123 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human HLA-DRB1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human HLA-DRB1 |
| Subcellular Locations | Cell membrane Endoplasmic reticulum membrane Endosome membrane Golgi apparatus Late endosome membrane Lysosome membrane Single-pass type I membrane protein trans-Golgi network membrane |
| Swiss Prot | P01911,P01912,Q29974 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. |