Anti-CHEK1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-CHEK1 Polyclonal Antibody

品牌:solarbio | 货号:K005372P

英文名称 Anti-CHEK1 Polyclonal Antibody
宿主 Rabbit
别名 CHK1
应用 WB IHC IF
稀释比例 WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 54kDa
Gene ID 1111
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human CHEK1
性状 液体
Public Immunogen Range A synthetic peptide of human CHEK1
Subcellular Locations Cytoplasm Nucleus centrosome cytoskeleton microtubule organizing center
Swiss Prot O14757
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.