Anti-PIWIL4 Polyclonal Antibody
品牌：solarbio | 货号：K006819P
| 英文名称 | Anti-PIWIL4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | HIWI2;MIWI2 |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 97kDa |
| Gene ID | 143689 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PIWIL4 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PIWIL4 |
| Subcellular Locations | Nucleus |
| Swiss Prot | Q7Z3Z4 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. |