Anti-RAF1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-RAF1 Polyclonal Antibody

品牌:solarbio | 货号:K008133P

英文名称 Anti-RAF1 Polyclonal Antibody
宿主 Rabbit
别名 NS5;CRAF;Raf-1;c-Raf;CMD1NN
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:25-100.
交叉反应 Human Mouse Rat
蛋白分子量 73kDa
Gene ID 5894
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human RAF1
性状 液体
Public Immunogen Range Recombinant protein of human RAF1
Subcellular Locations cytoplasm
Swiss Prot P04049
克隆类型 Polyclonal Antibody
背景资料 This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.