Anti-CD2AP Polyclonal Antibody
品牌:solarbio | 货号:K005464P
英文名称 |
Anti-CD2AP Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
CMS |
应用 |
WB |
稀释比例 |
WB 1:500-2000. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
71kDa |
Gene ID |
23607 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human CD2AP |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human CD2AP |
Subcellular Locations |
Cell projection Cytoplasm cytoskeleton ruffle |
Swiss Prot |
Q9Y5K6 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. |