Anti-KCNN3 Polyclonal Antibody
品牌:solarbio | 货号:K004334P
英文名称 |
Anti-KCNN3 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
KCa2.3;SK3;SKCA3;hSK3 |
应用 |
WB |
稀释比例 |
WB 1:500-2000. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
82kDa |
Gene ID |
3782 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human KCNN3 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human KCNN3 |
Subcellular Locations |
Membrane Multi-pass membrane protein |
Swiss Prot |
Q9UGI6 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |