Anti-CDKN2A Polyclonal Antibody
品牌：solarbio | 货号：K007688P
| 英文名称 | Anti-CDKN2A Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ARF;MLM;P14;P16;P19;CMM2;INK4;MTS1;TP16;CDK4I;CDKN2;INK4A;MTS-1;P14ARF;P19ARF;P16INK4;P16INK4A;P16-INK4A |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 17/11/14kDa |
| Gene ID | 1029 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human CDKN2A |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human CDKN2A |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P42771 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.? |