Anti-F13A1 Polyclonal Antibody
品牌：solarbio | 货号：K008249P
| 英文名称 | Anti-F13A1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | F13A |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:15-50. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 83kDa |
| Gene ID | 2162 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human F13A1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human F13A1 |
| Subcellular Locations | Secreted Cytoplasm |
| Swiss Prot | P00488 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. |