Anti-F13A1 Polyclonal Antibody
品牌:solarbio | 货号:K008249P
英文名称 |
Anti-F13A1 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
F13A |
应用 |
WB IHC |
稀释比例 |
WB 1:200-1000. IHC 1:15-50. |
交叉反应 |
Human Mouse |
蛋白分子量 |
83kDa |
Gene ID |
2162 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human F13A1 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human F13A1 |
Subcellular Locations |
Secreted Cytoplasm |
Swiss Prot |
P00488 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. |