Anti-Cystatin C Polyclonal Antibody
品牌:solarbio | 货号:K008373P
英文名称 |
Anti-Cystatin C Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
AD8;Cst3;ARMD11;Cystatin 3 |
应用 |
WB IHC |
稀释比例 |
WB 1:1000-5000. IHC 1:50-200. |
交叉反应 |
Human |
蛋白分子量 |
16kDa |
Gene ID |
1471 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human CST3 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human CST3 |
Subcellular Locations |
Cytoplasm |
Swiss Prot |
P01034 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. |