Anti-MMP2 Polyclonal Antibody
品牌：solarbio | 货号：K004386P
| 英文名称 | Anti-MMP2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CLG4;CLG4A;MMP-2;MMP-II;MONA;TBE-1 |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 74kDa |
| Gene ID | 4313 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human MMP2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human MMP2 |
| Subcellular Locations | Cytoplasm Membrane Mitochondrion Nucleus Secreted extracellular matrix extracellular space |
| Swiss Prot | P08253 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. |